Deletion of the long arm of chromosome 6 is frequently observed in acute lymphocytic leukemia (ALL), in chronic lymphocytic leukemia (CLL), in prolymphocytic leukemia and non-Hodgkin lymphomas. The deletion often includes the MYB gene.
The detection is based on a custom MLPA technique, using multiple probes in the region under investigation.
This test may also be applied in combination with:
- Karyotyping of bone marrow cells combined with molecular detection of multiple chromosomal rearrangements
- Multicolor karyotype (M-FISH)