The result of the t(4;14) translocation is the formation of the hybrid gene IGH/FGF3, an indication of multiple myeloma. The translocation is detected through FISH, using specific custom-labeled DNA probes, from at least 100 bone marrow cell nuclei.
This test may also be applied in combination with:
- Karyotype analysis of bone marrow cells, combined with molecular detection of multiple chromosomal rearrangements
- Multicolor karyotype (M-FISH)